Isoxazole moiety is an important five-membered heterocycle containing one oxygen atom with nitrogen[1]. Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for chemists and pharmacologists from research groups all over the world [2]. Isoxazole-based heterocycles are most bountiful among the biologically active compounds [1], and thanks to their usually low cytotoxicity, isoxazole derivatives are popular scaffolds for the development of new agents with variable biological activities, such as antimicrobial, antiviral, anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or anti-diabetic properties[2-7].
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