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最新药物分子砌块-2021/06 2021/06/06 10:19:03

新品推荐 - 2021 年 06 月

In recent years, an increased interest in oxadiazoles has emerged in drug discovery research, as well as in other areas of academia ^[1]. Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms^[2]. Among the stable isomers, the 1,3,4- and the 1,2,4-isomers have received considerable attention, in particular, because of their inherent role as bioisosteres for carboxylic acid derivatives. Accordingly, the literature is rich in examples of 1,3,4-oxadiazole-containing structures displaying antimicrobial, anticonvulsant, anti-inflammatory, antitumor, antiviral activity etc.^{[1, 3-7]}.

A series of medicinal products containing 1,3,4-oxadiazole has been firmly incorporated in medical practice — A series of medicinal products containing 1,3,4-oxadiazole has been firmly
incorporated in medical practice

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