最新药物分子砌块-2020/7

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最新药物分子砌块-2020/7 2020/7/22 9:53:29

新品推荐 - 2020年7月

有机合成砌块、合成试剂、特色医药中间体

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Cyclobutane derivatives, as molecular building blocks, has gained increasing importance. They can be used as starting materials for the synthesis of both acyclic and cyclic systems,including carbo- and heterobicyclic and oligocylic compounds^[1].They aslo are witnessing significant prominence in medicinal chemistry discovery programs,and the various reports that have documented the benefits accompanying their use in discovery candidates are driving the increased visibility.The range of advantages includes structural novelty along with improved physicochemical and pharmaco-kinetic properties^[2].More and more lead compounds containing cyclobutane skeletons have been designed, synthesized and separated^[3-7].

A series of medicinal products containing cyclobutane has been firmly incorporated in medical practice.

A series of medicinal products containing cyclobutane has been firmly incorporated
in medical practice.

[1] Chemical Reviews (2003), 103(4), 1485-1537.
[2] Chemical Reviews (2014), 114(16), 8257-8322.
[3] European Journal of Medicinal Chemistry (2006), 41(2), 201-207.
[4] European Journal of Medicinal Chemistry (2006), 41(5), 664-669.
[5] Journal of Medicinal Chemistry (2012), 55(1), 250-267.
[6] Journal of Medicinal Chemistry (2014), 57(4), 1252-1275.
[7] Journal of Natural Products (2018), 81(2), 307-315.

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上一篇：Angew. Chem. Int. Ed. | 利用一类新型的喹啉噁唑啉配体实现γ-丁烯酸内酯衍生物的高对映选择性合成下一篇：Nat. Commun.|新型三氟甲氧基化试剂（TFMS）在有机合成中的新应用

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