最新药物分子砌块-2021/01 - 乐研试剂

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最新药物分子砌块-2021/01 2021/01/15 12:05:43

新品推荐 - 2021 年 01 月

7-azaindole is well known as a kinase privileged fragment^[1-2] and has been incorporated into many kinase inhibitors as a hinge-binding element^[3]. It has multiple modification sites where various substituents can be readily attached. Therefore recent years have seen growing interest in this 7-azaindole scaffold and more than 100000 chemical structures having 7-azaindole framework have been registered in the CAS chemical database, which is steadily increasing by the synthetic innovation and enrichment of commercially available derivatives^[3]. Most importantly, 7-azaindole fragment have been used as a starting point of medicinal chemistry targeting various kinases^[3]. According to statistics, many drug molecules containing 7-azindole have been marketed or are currently under clinical study^[3-8]..

A series of medicinal products containing 7-azaindole has been firmly incorporated in medical practice. — A series of medicinal products containing 7-azaindole has been firmly
incorporated in medical practice.

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