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最新药物分子砌块-2020/11 2020/11/15 11:05:43

新品推荐 - 2020 年 11 月

The pyrazine unit is an important structural motif that widely existed in many bioactive and nature compounds.^[1] Pyrazine derivatives have attracted wide pharmaceutical interests because of their potential uses in the treatment of psychiatric disorders, neurological diseases (e.g., stress, anxiety and depression), and cardiovascular disorders.^[2] They are reported to modulate the activity of CRF1 (corticotropin-releasing factor 1) receptors. Besides, they are also versatile building blocks in the synthesis of VCAM-1 (vascular cell adhesion molecule-1) inhibitors, pyrazine alkaloids (antineoplasmic activity), and imidazopyrazin coelenterazine (bioluminescent). ^[2] In recent years, pyrazine scaffold has been found in more and more drug molecules.^[3-7]

A series of medicinal products containing pyrazine has been firmly incorporated in medical practice. — A series of medicinal products containing pyrazine has been firmly
incorporated in medical practice.

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