Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
应用
2-(2-Methoxyphenyl)-4,4-dimethyl-4,5-dihydrooxazole is an intermediate in the synthesis of Candesartan-d4, the labeled analogue of Candesartan (C175575), an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.
参考文献
Kaur, N., et al.: Bioorg. Med. Chem., 16, 10210 (2008); Funao, K., et al.: Mol. Med. Rep., 2, 193 (2009); Yoshikawa, M., et al.: J. Cardiovas. Pharmacol., 53, 179 (2009); Palaniyappan, A., et al.: Mol. Cell. Biochem., 321, 9 (2009)
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