(2R)-Ethylpyrrolidine Hydrochloride is used as a reagent in the synthesis of 6-(4-pyrimidinyl)-1H-indazole derivatives as PDK1 kinase inhibitors useful in treatment of cancer, immune, metabolic and other kinase-mediated diseases. Also used as a reagent in the synthesis of aryloxazole derivatives as histamine H3 receptor antagonists or inverse agonists.
参考文献
Axten, J.M., et al. PCT Int. Appl. WO 2010059658 A1 20100527. May 27, 2010; Beavers, L.S., et al. PCT Int. Appl. WO 2006019833 A1 20060223. Feb 23, 2006
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