英文名称
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride
(1S,4R)-4-(2-氨基-6-氯-9H-嘌呤-9-基)-2-环戊烯-1-甲醇盐酸盐
分子式
C11 H12 Cl N5 O . Cl H
纯度
95%
网页展示纯度为入库指导纯度值，各批次间存在一定差异，实际纯度以收货为准
Off-White to Beige to Brown Solid
DMSO (Slightly), Methanol (Slightly)
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
(1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol Hydrochloride (Abacavir Related Compound C) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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