产品编号
1039709
CAS 号
67812-42-4
中文名称
盐酸去甲维拉帕米
MDL 号
MFCD00078605
分子量
477.04
存储条件
2-8°C, sealed storage, away from moisture and light
网页展示纯度为入库指导纯度值,各批次间存在一定差异,实际纯度以收货为准
熔点
155-160 °C
沸点
闪点
旋光
描述
TPSA
72.74
LogP
5.17268
H_Acceptors
6
H_Donors
1
Rotatable_Bonds
13
[1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.
[2]. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8.
[3]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.
[4]. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.
[5]. Amy C Young, et al. Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation. 2009 May;80(5):591-3.
警示图
警示词
Danger
危险申明
H302-H315-H319-H335
警告申明
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
GHS 编码
GHS06,GHS08
危险类别
6.1
UN 编码
2811
包装等级
Ⅲ
现货供应
专业护航
售后无忧
品质保障
无需凑单