A potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
参考文献
Greiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008);
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