Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
A major oxidative metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig.
参考文献
Clarke, E., et al.: Cancer Res., et al.: 56, 105 (1996), Itani, S., et al.: Metabolism, 50, 553