Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
Duloxetine Hydrochloride acts as an antidepressant and a dual serotonin and norepinephrine reuptake inhibitor (SNRI) (1,2). Exhibits linear pharmacokinetics in mice and is not associated in any drastic changes of blood pressure or heart rate (3).
参考文献
1. Wong, D. et al.: Neuropsychopharmacology. 1993 Jan;8(1):23-33.2. Fuller, R. et al.: J Pharmacol Exp Ther. 1994 Apr;269(1):132-6.3. Sharma, A. et al.: J Clin Pharmacol. 2000 Feb;40(2):161-7.