Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用
6-Desacetyl-6-bromo-N-Boc Palbociclib is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Also, it is derived from 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one (B682195), which is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.
参考文献
Finn, R., et al.: Breast Cancer Res., 11, 5 (2009); Li, X., et al.: PCT Int. Appl., WO 2014183520 A1 20141120 (2014)
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